With Purdue’s millions behind him, his message, which dovetailed with their marketing plans, was hugely magnified.” 89 As one organizer of CME seminars, who worked with Portenoy and Purdue, pointed out, “had Portenoy not had Purdue’s money behind him, he would have published some papers, made some speeches, and his influence would have been minor.It was a compelling message: ‘Docs have been letting patients suffer nobody really gets addicted it’s been studied.’” 88 The megaphone for Portenoy is Purdue, which flies in people to resorts to hear him speak. Andrew Kolodny, cofounder of Physicians for Responsible Opioid Prescribing, described him “lecturing around the country as a religious-like figure. A respected leader in the field of pain treatment, Dr. One of the most prominent KOLs for the Manufacturing Defendants’ opioids was Dr.KOLs also served on committees and helped develop guidelines such as the 2009 Guidelines described above that strongly encouraged the use of opioids to treat chronic pain. The KOLs gave the impression they were independent sources of unbiased information, while touting the benefits of opioids through their presentations, articles, and books.86 For example, doctors who were invited to these all-expenses-paid weekends in resort locations like Boca Raton, Florida, and Scottsdale, Arizona, wrote twice as many prescriptions as those who did not attend. It is well documented that this type of pharmaceutical company symposium influences physicians’ prescribing, even though physicians who attend such symposia believe that such enticements do not alter their prescribing patterns.Although often couched in scientific certainty, the Manufacturing Defendants’ messages were false and misleading, and helped to ensure that millions of Americans would be exposed to the profound risks of these drugs. 85 The Manufacturing Defendants used these trips and programs-many of them lavish affairs-to incentivize the use of opioids while downplaying their risks, bombarding doctors with messages about the safety and efficacy of opioids for treating long-term pain. The Manufacturing Defendants also identified doctors to serve as speakers or attend all-expense-paid trips to programs with speakers.The Manufacturing Defendants paid these KOLs substantial amounts to present at Continuing Medical Education (“CME”) seminars and conferences, and to serve on their advisory boards and on the boards of the various front groups. Known as “ Key Opinion Leaders” or “KOLs,” these medical professionals were often integrally involved with the front groups described above. The Manufacturing Defendants retained highly credentialed medical professionals to promote the purported benefits and minimal risks of opioids.Pages 55 of 147 to 59 of 147 Doctors (3 examples) advocating for Manufacturing Defendants’ opioids. McKesson, AmerisourceBergen, and Cardinal Health (together “ Distributor Defendants”) account for approximately 85% of all drug shipments in the United States. MCKESSON CORPORATION AMERISOURCEBERGEN DRUG CORPORATION and JOHN AND JANE DOES 1 THROUGH 100, INCLUSIVEĭefendants Purdue, Endo, Janssen, Cephalon, Actavis, and Mallinckrodt are collectively referred to as the “ Manufacturing Defendants.” f/k/a WATSON PHARMA, INC MALLINCKRODT PLC MALLINCKRODT, LLC CARDINAL HEALTH, INC. ALLERGAN PLC f/k/a ACTAVIS PLC WATSON PHARMACEUTICALS, INC n/k/a ACTAVIS, INC. JOHNSON & JOHNSON T EVA PHARMACEUTICALS INDUSTRIES, LTD. UNITED STATES DISTRICT COURT WESTERN DISTRICT OF WASHINGTON AT TACOMA Taken from: Pierce County Amended Complaint 4829-7649-5461 v.2.docx, My litigation attorney friend Jack will probably comment. Much of this is a C&P straight from what was filed by Pierce County in the US District Court (Federal) Western District of Washington at Tacoma. If you walk away after reading this without saying “wow,” then I missed my goal or you are thickheaded. Seventy-two percent alleged addiction was rare in patients treated with opioids.īelow, you will read about three doctors or “ Key Opinion Leaders” (or “KOLs,”) and how they handled prescribing Oxycontin, etc. I am interested in the erroneous citations using the Jick and Porter letter considering the safety of prescribing opioids. Do not confuse this with the Jick and Porter letter (which I will follow-up on) and the 2017 article A 1980 Letter on the Risk of Opioid Addiction | NEJM. Lawsuit by Pierce County against various drug distributors and manufacturers, In this instance, I am going to guess they are talking about Opioid pills such as Purdue’s Oxycontin. Then I am not the one who may choose to read it. I do not believe this (below) to be long.
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